HHV-1 = predominantly oral – HHV-2 = predominantly genital

Type Synonym Subfamily Primary Target Cell Pathophysiology Site of Latency Means of Spread
HHV-1 Herpes simplex virus-1 (HSV-1) α (Alpha) Mucoepithelial Oral and/or genital herpes (predominantly orofacial), as well as other herpes simplex infections Neuron Close contact
HHV-2 Herpes simplex virus-2 (HSV-2) α Mucoepithelial Oral and/or genital herpes (predominantly genital), as well as other herpes simplex infections Neuron Close contact (sexually transmitted disease)

There are eight distinct viruses in this family known to cause disease in humans