IgM and IgG – HERPES

In the initial (primary infection) phase of the infection, immunoglobulin M (IgM) antibodies are produced and as these levels drop (and become undetectable) immunoglobulin G (IgG) levels rise and remain detectable. Upon reinfection, IgM antibodies usually do not rise again but IgG levels will increase. Thus an elevated IgM titre indicates recent primary infection, while the presence of IgG suggests past infection orimmunization.

http://en.wikipedia.org/wiki/Seroconversion